Lack of Mutations in PIK3CA, p14ARF, p16INK4a and p21Waf1/Cip1 in Phenytoin-Induced Gingival Overgrowth

Seizure episodes associated with generalized tonic clonic or partial seizure disorder is a life style debilitating disease. Several drugs have been developed, which are in use to control seizure episodes include carbamazepine, ethosuximide, felbamate, lamotrigine and phenytoin (Das et al., 2012; Bialer et al., 2013). While a long list of drug exists, phenytoin is preferred drug of choice as it: i) can be given intravenously to rapidly control active seizures, ii) is cost effective, and iii) has prolonged duration of action (Brodie et al., 2012). However, administration of phenytoin even at therapeutic dosage